Abstract: Objective to study the sentinel lymph node biopsy neoadjuvant chemotherapy for breast cancer after value of clinical application. Methods from September 2007 November 2010 during the Ⅱ 46 cases treated patients with breast cancer, Ⅲ period after neoadjuvant chemotherapy axillary lymph node ultrasound negative person as the research object. 46 patients sentinel lymph node biopsy axillary lymph node cleaning the subtotal standards. All the sentinel lymph node do pathology and immunohistochemical inspection. All the sentinel lymph node do regular pathological examination. Results the sentinel lymph node biopsy success rate, false negative rate, sensitivity, specificity and accuracy, respectively, negatie predictie positie predictie reprinted, 3.7%, 96.3%, 100%, nine, 100%, sentinel lymph node biopsy 94.1%. Conclusion with ultrasound can accurate evaluation neoadjuvant chemotherapy axillary lymph node status after breast cancer patients to decide whether you need, do armpit lymph node dissection have certain reference value.

摘要： 目的 研究前哨淋巴结活检在乳腺癌新辅助化疗后的临床应用价值。方法 选择我院2007年9月至2010年11月期间收治的46例Ⅱ、Ⅲ期乳腺癌患者，接受新辅助化疗后超声检查腋窝淋巴结阴性者为研究对象。所有患者前哨淋巴结活检后行乳腺癌改良根治术及标准腋窝淋巴结清扫，所有前哨淋巴结行病理和免疫组化检查，非前哨淋巴结行常规病理检查。结果 前哨淋巴结活检的成功率、假阴性率、灵敏度、特异性、精确性、阳性预测值、阴性预测值分别是93.5%，3.7%，96.3%，100%，97.7%，100%，94.1%。结论 前哨淋巴结活检结合超声可以较准确的评价新辅助化疗后乳腺癌的腋窝淋巴结状态，对于决定患者是否需要行腋窝淋巴结清扫有一定参考价值。

关键词: 乳腺癌, 前哨淋巴结活检, 新辅助化疗, 超声, breast cancer, sentinel lymph node biopsy, neoadjuvant chemotherapy, ultrasound