Abstract: Objective To observe concentration changes and intervention of somatostatin of MMP-2 and TIMP-2 of plasma after hepatectomy in patients with liver cancer. Methods Twenty cases received hepatectomy were randomly divided into teo groups namely conventional therapeutic group and somatostatin treatment group. Ten cases were in each group. The somatostatin was given in the somatostatin treatment group. Results The plasma concentration of MMP-2 was significantly increased and The plasma concentration of TIMP-2 was significantly decreased after hepatectomy. The administration of somatostatin could decrease the plasma concentration of MMP-2 and increase the plasma concentration of MMP-2. Conclusions The administration of somatostatin after hepatectomy might suppress of recurrence after surgery.

摘要： 目的 观察肝癌患者肝切除后血浆MMP-2和TIMP-2浓度变化及生长抑素干预。方法 20例肝癌切除患者随机分成2组，常规治疗组和生长抑素治疗组，每组各10例，生长抑素治疗组给于生长抑素治疗。结果 肝切除后，血浆MMP-2浓度明显上升，血浆TIMP-2浓度明显下降，应用SST能降低MMP-2浓底，升高TIMP-2浓度。结论 肝切除后应用SST可能对抑制肿瘤复发有益

关键词: 肝癌, 生长抑素, MMP-2, TIMP-2, hepatocellular carcinoma, somatostatin , MMP-2 , TIMP-2