【Abstract】 Objective To evaluate the clinical application value of interventional ultrasound therapy in thyroid benign nodules. Methods 246 patients with thyroid benign nodules were treated with Percutaneous ethnol injection(PEI)and radioactive colloidal chromium phosphated-32(RCCP)under the guidance of ultrasound, and the therapeautical results were evaluated 3 m and 12m post-treatment. Results Both ethnol and radioactive colloidal chromium phosphate-32 had significant effects in reducing the nodule size, the total effective rate was 91.8% , 93.4%and91.9% , 96.8%post 3m and 12m respectively, there was no obvious difference(P>0.05).But there was better effect in the solid lesion than in the others, the total effective rate was 100% and 85.0% respectively post 12m therapy(P<0.01).But for the solid lesion,PEI was superior to RCCP, the effective rate was90.9% and 77.8%(P<0.05),but no difference between both methods in cyst lesions. Conclusion Interventional ultrasound therapy had practical clinical value in the treatment of thyroid benign nodules.