Abstract: 【Abstract】 To summarize the relationship of microRNA（miRNA）to metastasis and invasion of thyroid cancer. Domestic and international publications involving the relationship of miRNA to thyroid cancer were screened and reviewed. miRNA played a key role in the process of thyroid cancer metastasis. According to its function, it could be distinguished from cancer-promoting gene（such as miR-221, miR-222, miR-146b, etc. ）to suppressor gene（such as miR-199a, miR-204, etc. ）. The more detailed experimental studies about the relationship of miRNA to metastasis and invasion of thyroid cancer need to be researched in order to provide a new method for the diagno sis and treatment of thyroid cancer metastasis and invasion.

Key words: Metastasis, MicroRNA, Invasion, Thyroid cancer

摘要：

总结microRNA（miRNA）与甲状腺癌侵袭、转移关系的研究进展。检索并筛选近年来国内外发表的有关miRNA与甲状腺癌侵袭、转移关系的文献并对其进行综述。研究表明许多miRNA在甲状腺癌发生、发展与侵袭、转移过程中都起着关键作用，按其作用可分为促癌miRNA（miR-221、miR-222、miR-146b等）和抑癌miRNA（miR-199a、miR-204等）两类。因此，miRNA调控甲状腺癌侵袭及转移的具体过程还需要更多、更详细的研究。

关键词: 侵袭, 甲状腺癌, 转移, microRNA