Abstract: The incidence of breast cancer is increasing year by year. Compared with other organ metastasis, the prognosis of breast cancer patients with liver metastases is usually poor. At present, there is no guideline for diagnosis and treatment of liver metastasis in breast cancer patients. The purpose of this paper is to provide ideas and suggestions for clinical diagnosis and treatment of breast cancer with liver metastases. Reviewed the clinical features, pathogenesis and therapy ofbreast cancer patients with liver metastases. When liver metastasis occurs, patients usually had no obvious symptoms or signs.It is strongly recommended thatliver metastasis should be pathologically diagnosed by percutaneous liver puncture. With the development of new drugs and therapies for breast cancer, the survival rate of patients with liver metastases has improved significantly, and some patients can also benefit from local treatment. Effective systemic therapy is the key to improve the survival of breast cancer patients with liver metastases. Some selected patients may also benefit from local treatment

Key words: breast cancer, liver metastasis, local treatment, stereotactic radiotherapy, molecular targeted therapy, chemotherapy

摘要： 乳腺癌发病人数逐年攀升,相较于其他部位转移的患者,乳腺癌肝转移患者通常预后较差。目前国内外尚无针对乳腺癌肝转移诊疗的指南。本文旨在为乳腺癌肝转移的临床诊疗提供一定的思路和依据。本文对乳腺癌肝转移临床特点、发病机制的研究现状与治疗进展进行综述。早期肝转移患者往往没有明显症状或体征,考虑肝转移的患者最好行影像学引导下穿刺确诊。随着乳腺癌新的药物及疗法的开发,肝转移患者生存较前有显著改善,部分患者也可从局部治疗中获得生存获益。对于发生肝转移的乳腺癌患者,有效的全身治疗是延长患者生存期的关键,部分经过选择的患者也可同时从局部治疗中获益。

关键词: 乳腺癌, 肝转移, 局部手术治疗, 立体定向放射治疗, 分子靶点治疗, 化疗