Research progress on surgical omission after neoadjuvant therapy for breast cancer

doi:10.3969/j.issn.1009-976X.2025.04.010

Abstract

Abstract: In the context of modern multidisciplinary therapy, the improvement of neoadjuvant therapy （NAT） has increased the pathologic complete response （pCR） rate in breast cancer patients. Compared to patients with residual disease, those achieving pCR demonstrate superior prognosis. Accurate non-surgical identification of pCR patients may allow for the omission of breast surgery, but the success of this strategy hinges on diagnostic precision. Preliminary data exist regarding the accuracy of vacuum-assisted breast biopsy （VABB） for assessing tumor response after neoadjuvant therapy in early-stage breast cancer, as well as the feasibility of omitting surgery based on biopsy findings. However, several unresolved issues remain regarding breast surgery omission after NAT, and further clinical trial validation is needed. This review aims to explore the feasibility of omitting breastsurgery in patients who achieve pCR after neoadjuvant therapy.

Key words: breast cancer, neoadjuvant therapy, omission of surgery

摘要： 在现代多学科治疗背景下,新辅助治疗（NAT）方案的改进显著提高了乳腺癌患者的病理学完全缓解率（pCR）。与存在残留病灶的患者相比,获得pCR的患者预后更佳。通过非手术方式准确识别pCR患者,可能使其豁免乳腺手术,但这一策略的成功依赖于诊断的准确性。早期乳腺癌患者新辅助治疗后通过真空辅助活检（VABB）评估肿瘤反应的准确性,以及根据活检评估结果豁免手术的安全性已有初步数据,但新辅助治疗后豁免乳腺手术尚有诸多问题尚待解决,仍需要进一步临床研究的验证。本综述旨在探讨新辅助治疗后pCR患者豁免乳腺手术的可行性。

关键词: 乳腺癌, 新辅助治疗, 豁免手术

CLC Number:

R737.9

YAN Meng-xin, CHEN Xiang. Research progress on surgical omission after neoadjuvant therapy for breast cancer[J]. Lingnan Modern Clinics In Surgery, 2025, 25(04): 273-280.

严孟欣, 陈翔. 乳腺癌新辅助治疗后豁免手术研究进展[J]. 岭南现代临床外科, 2025, 25(04): 273-280.

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