Effect of laparoscopic sleeve gastrectomy on thyroid function in obese patients

doi:10.3969/j.issn.1009-976X.2025.02.005

Abstract

Abstract: Objective To explore the effects of laparoscopic sleeve gastrectomy （LSG） on thyroid function in obese patients and the potential factors affecting thyroid function after surgery. Methods Sixty-seven obese patients who received standardized LSG in Zhengzhou People's Hospital from October 2019 to October 2021 and completed 1-year follow-up were selected as the study objects. The height, weight, thyroid function indexes （TSH、FT3、FT4）, LDL, HDL and other clinical data before and 1 year after LSG were retrospectively collected. The changes of parameters before and after operation were calculated. The related indexes of thyroid function were compared before and 1 year after surgery, and the potential factors affecting the changes of TSH, FT3 and FT4 after surgery were explored. Results TSH level decreased from （2.84±1.60） mIU/L to （1.45±0.71） mIU/L 1 year after surgery （P<0.001）. FT3 decreased from （5.51±0.58） pmol/L to （5.16±0.51） pmol/L （P<0.001）, and there was no significant difference in FT4 level 1 year after operation. Postoperative BMI （P<0.001） and LDL （P=0.013） were important factors affecting TSH changes. The change of postoperative LDL （P=0.004） was an important factor affecting the change of postoperative FT3. Conclusion LSG has a significant effect on thyroid function in obese patients, and the changes of body mass index （BMI） and LDL are important parameters to predict thyroid function after surgery.

Key words: laparoscopic sleeve gastrectomy, obesity, thyroid function, metabolic syndrome

摘要： 目的探究腹腔镜胃袖状切除术（LSG）对肥胖患者甲状腺功能的影响及影响术后甲状腺功能的潜在因素。方法选取2019年10月至2021年10月于郑州人民医院行标准化LSG并完成1年随访的67例肥胖患者为研究对象。回顾性收集LSG术前及术后1年身高、体重、甲状腺功能相关指标（TSH、FT3、FT4）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）等临床资料,计算术前及术后各参数变化值。比较术前及术后1年甲状腺功能相关指标,并探究影响术后TSH、FT3、FT4变化的潜在因素。结果术后1年TSH从（2.84±1.60）mIU/L降至（1.45±0.71）mIU/L（P<0.001）,FT3从（5.51±0.58）pmol/L降至（5.16±0.51）pmol/L（P<0.001）,术后1年FT4水平较术前无明显差异。术后体质指数（BMI）（P<0.001）、LDL（P=0.013）变化是影响术后TSH的重要因素。术后LDL（P=0.004）变化是影响术后FT3的重要因素。结论 LSG对肥胖患者甲状腺功能有显著影响,术后BMI、LDL变化是预测术后甲状腺功能的重要参数。

关键词: 腹腔镜胃袖状切除术, 肥胖症, 甲状腺功能, 代谢综合征

CLC Number:

R656.6

REN Xue-kang, LI Rong-zhen, ZHU Shao-gong, XIA Yun-zhan. Effect of laparoscopic sleeve gastrectomy on thyroid function in obese patients[J]. Lingnan Modern Clinics In Surgery, 2025, 25(02): 112-117.

任雪康, 李荣振, 朱少功, 夏云展. 腹腔镜胃袖状切除术对肥胖患者甲状腺功能的影响研究[J]. 岭南现代临床外科, 2025, 25(02): 112-117.

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