Identification and validation of a carbohydrate metabolism related key gene associated with fibroblast in abdominal aortic aneurysm

doi:10.3969/j.issn.1009-976X.2026.01.005

Abstract

Abstract: Objective To explore the potential role of the （alcohol dehydrogenase 1B, ADH1B）ADH1B gene in abdominal aortic aneurysms （AAA）. Methods Utilizing bioinformatics techniques, we conducted a comprehensive analysis of transcriptome and single-cell data from human AAA and normal abdominal aorta tissue samples. The metabolism-related marker gene ADH1B was identified using logistic regression analysis of carbohydrate metabolism datasets. Results The fibroblast ADH1B gene may be involved in protecting against the development of AAA by modulating smooth muscle cell phenotypic changes. Conclusion The ADH1B gene appears to have a protective role in abdominal aortic aneurysms.

Key words: ADH1B, abdominal aortic aneurysms, bioinformatics

摘要： 目的探讨乙醇脱氢酶1B基因（ADH1B）在腹主动脉瘤中的潜在作用。方法采用生物信息学技术,综合分析人类腹主动脉瘤和正常腹主动脉组织样本的转录组和单细胞数据。通过参考碳水化合物代谢数据集,采用逻辑回归筛选出代谢相关标志基因ADH1B。结果成纤维细胞中的ADH1B基因可能通过调节平滑肌细胞表型转换,参与抑制腹主动脉瘤的发生发展。结论 ADH1B基因对腹主动脉瘤具有保护作用。

关键词: ADH1B, 腹主动脉瘤, 生物信息学

CLC Number:

R654.2

LI Gen, ZHAO Ziniu, SHI zhanyue. Identification and validation of a carbohydrate metabolism related key gene associated with fibroblast in abdominal aortic aneurysm[J]. Lingnan Modern Clinics In Surgery, 2026, 26(01): 33-41.

李根, 赵子牛, 石展岳. 成纤维细胞乙醇脱氢酶1B基因在腹主动脉瘤中的潜在作用[J]. 岭南现代临床外科, 2026, 26(01): 33-41.

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