Abstract: This study retrospectively analyzed the clinical data, pathological findings, immunohistochemical results, and genetic test outcomes of a patient diagnosed with Cribriform Morular Thyroid Carcinoma （CMTC）. Postoperative histological examination showed the cribriform and morular patterns. Immunohistochemistry demonstrated that TTF-1, estrogen receptor （ER）, and progesterone receptor （PR） were positively expressed in cribriform structures, while absent in the morular structures. β-catenin showed diffuse positivity in the nucleus and cytoplasm, and the Ki-67 proliferation index was consistently below 5%。CMTC, a rare variant of thyroid carcinoma, is distinguished by its unique pathological features and typically favorable prognosis. Accurate morphological assessment and immunohistochemical profiling are essential for diagnosis. Additionally, screening for Familial Adenomatous Polyposis （FAP） and regular follow-up of affected patients and their families hold significant clinical relevance.

Key words: cribriform morular thyroid carcinoma, familial adenomatous polyposis, clinical and pathological features

摘要： 本文通过回顾性分析了1例CMTC患者的临床资料、病理组织学表现、免疫组化结果及基因检测结果,术后病理组织学揭示筛状、桑葚样结构。免疫组化显示β-catenin在细胞核和胞质中弥漫阳性,Ki-67指数通常低于5%,筛状结构中TTF-1、ER、PR表达阳性,而桑葚样结构中不表达。CMTC作为一种罕见的甲状腺癌亚型,具有独特的病理学特征和较为乐观的预后。形态学观察和免疫组化染色对于确诊至关重要,同时对患者和家属进行FAP的筛查和随访管理具有重要的临床意义。

关键词: 筛状桑葚型甲状腺癌, 家族性腺瘤性息肉病, 临床病理特征