Observation of the effect of low-dose dexmedetomidine combined with propofol titration induction during transvaginal oocyte retrieval

doi:10.3969/j.issn.1009-976X.2020.03.018

Abstract

Abstract: Objective To observe the effect of dexmedetomidine combined with propofol titration induction on the safety and comfort of patients undergoing transvaginal oocyte retrieval. Methods 100 patients undergoing transvaginal oocyte retrieval from May 2019 to October 2019 in Foshan Maternal and Child Health Hospital were randomized into group D （dexmedetomidine combined with propofol group） and group C （propofol group） according to the Random-number Table, with 50 cases in each group. That the MOSS/A reach 0 was used as the end point dring titration induction. The mean arterial pressure （MAP）, heart rate （HR）, pulse oxygen saturation （SpO₂） were compared between the two groups at different time points. Propofol dosage, patient satisfaction and adverse reactions were recorded. Results Propofol dosage in group D is lower than that in group C （P<0.05）. The frequency of respiratory depression, body movement during operation and postoperative abdominal pain in group D were significantly lower than those in group C （P<0.05）. There was no statistically significant in propofol-induced injection pain and comfort scores between the two group （P>0.05）. The incidence of bradycardia and hypotension in the two groups was not statistically significant （P>0.05）. Conclusion Compared with propofol alone, dexmedetomidine combined with propofol can reduce the dosage of propofol and the incidence of respiratory depression,body movement during operation and postoperative abdominal pain, so it is safer to be used during transvaginal oocyte retrieval.

Key words: propofol, transvaginal oocyte retrieval, dexmedetomidine

摘要： 目的观察经阴道取卵术中使用右美托咪定复合丙泊酚滴定麻醉对患者安全性、舒适性的影响。方法选择2019年5月至2019年10月在佛山市妇幼保健院生殖中心行择期经阴道取卵术的患者100例,根据随机数字表法分为D组（右美托咪定复合丙泊酚组）和C组（丙泊酚组）,每组各50例,两组均采用滴定给药方式,以MOSS/A镇静评分0分作为滴定终点。比较两组患者不同时间点的平均动脉压（MAP）、心率（HR）、脉搏氧饱和度（SpO₂）,记录丙泊酚用量、患者满意度及各种不良反应。结果 D组丙泊酚用量少于C组（P<0.05）,D组呼吸抑制、术中体动、术后腹痛等发生率显著低于C组（P<0.05）。两组患者丙泊酚注射痛、舒适度评分无统计学意义（P>0.05）,两组心动过缓、低血压发生率无统计学意义（P>0.05）。结论与单纯使用丙泊酚相比较,右美托咪定复合丙泊酚可减少丙泊酚用量,降低呼吸抑制、术中体动及术后腹痛发生率,可更加安全地运用于无痛取卵术。

关键词: 右美托咪定, 取卵术, 丙泊酚

CLC Number:

R614

LI Ling, LIU Guo-dong, YU Chun-yu, OUYANG Hui-wang, WU Jian, CAI Hong-mei. Observation of the effect of low-dose dexmedetomidine combined with propofol titration induction during transvaginal oocyte retrieval[J]. Lingnan Modern Clinics in Surgery, 2020, 20(03): 346-349.

李凌, 刘国栋, 于春宇, 欧阳辉旺, 武建, 蔡红梅. 小剂量右美托咪定复合丙泊酚滴定麻醉用于经阴道取卵术的效果观察[J]. 岭南现代临床外科, 2020, 20(03): 346-349.

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