Clinical research on treating advanced stage hepatocarcinoma with DC-CIK immunotherapy combined with TACE interventional therapy

doi:10.3969/j.issn.1009-976X.2014.05.002

Abstract

Abstract: 【Abstract】〓Objective〓To investigate the clinical effectiveness of transcatheter arterial chemoem-bolization (TACE) combined with DC-CIK in treating advanced stage hepatocarcinoma. Methods〓112 patients with advanced stage hepatocarcinoma were included in the study..Among them,64 cases received TACE combined with DC-CIK (group A) and 48 cases underwent TACE alone (group B). Blood routine, tumor makers, immune function were detected, analyzed in all patients and compared between two groups. Results〓The serum CD3+, CD4+, CD8+, CD19+, NK, CD3+/CD4+, CD3+/CD8+ cells in A group were increased than that in B group (P<0.05). The number of patients who were demonstrated remission and partial remission was increased in A group than that in B group(P<0.05). The death mumber in A group was less than in group at 6 months and 12 months of follow-up and no difference was found at 18 months of follow-up. Conclusion〓To a certain degree, TACE combined with DC-CIK would improve the immune function,increase in the near future curative effect for patients with advanced stage hepatocarcinoma.

Key words: Advanced hepatocarcinoma, TACE, DC-CIK, Tumor makers, Immune function　

摘要：

【摘要】〓目的〓探讨DC-CIK细胞免疫治疗联合介入治疗晚期肝癌的临床疗效。方法〓选择晚期原发性肝癌患者112例为研究对象,根据患者自愿情况分为TACE联合DC-CIK细胞免疫治疗组(A组,n=64)和TACE治疗组(B组,n=48),观察治疗前后血常规、肿瘤标志物、免疫功能及治疗效果。结果〓A组缓解率明显高于B组(78.12% VS 47.92%);治疗前后CD3+、CD4+、CD8+、CD19+、NK、CD3+/CD4+、CD3+/CD8+增加或减少值均高于B组;随访6个月、12个月,A组死亡病例明显低于B组(6.25% VS 16.67%, 1.78% VS 12.82%),但两组18个月的死亡病例数比较没有差异。结论〓TACE联合DC-CIK细胞免疫治疗一定程度上可改善免疫功能,提高近期疗效。

关键词: 晚期肝癌, TACE, DC-CIK, 肿瘤标志物, 免疫功能

CLC Number:

R735.7

ZuYuqi, Xue Ping, Jiang Xiaofeng, Wen Zilong, Zhang Dawei. Clinical research on treating advanced stage hepatocarcinoma with DC-CIK immunotherapy combined with TACE interventional therapy[J]. Lingnan Modern Clinics in Surgery, 2014, 14(05): 505-508.

祖余琪薛平蒋小峰温子龙张大伟. DC-CIK免疫治疗联合TACE介入治疗晚期肝癌的临床研究[J]. 岭南现代临床外科, 2014, 14(05): 505-508.

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