关键词: 低氧诱导因子-1, 肿瘤, 侵袭, 转移, Hypoxia inducible factor-1α, Neoplasms, Invasion, Metastasis

Abstract: Hypoxia is very common in solid tumor. Hypoxia-inducible factor-1α(HIF-1α) is the Transcription factor generally existed in mammal and human cells. Many hypoxia-responding genes can be activated by HIF-1α. It can facilitate malignant cells invasion and metastasis through affecting tumor cell’s capability of adhesion and migration, the degradation of extracellular matrix(ECM). Depressing the expression level of HIF-1α may inhibit malignant biological behaviour of tumor, thereby improving patient’s poor prognosis.