关键词: 胃癌, 进展期, 化疗

Abstract: 【Abstract】〓Objective〓To investigate the clinical efficacy and adverse reaction of different treatment methods for the progress of gastric cancer. Methods〓Sixty-six cases of advanced gastric cancer were chosen and divided into observation group (n=33) and control group (n=33). The patients in observation group were treated by SOX (S-1+oxaliplatin) chemotherapy. The controls were given FOX (oxaliplatin plus calcium folinate and fluorouracil) chemotherapy. The clinical efficacy, adverse reaction and survival time between two groups were compared between two groups. Results〓The effective percentage of observation group was 84.9% (28/33) and showed no significantly difference compared with that of the control group (24/33, 72.7%, χ2 =1.451, P<0.05). The side effects included granulopenia, thrombocytopenia, gastrointestinal upset, abnormal liver function. There was significant difference of the median survival times between two groups (t=7.733, P<0.05). Conclusion〓In the present study, S-1+oxaliplatin chemotherapy showed good efficacy, less adverse reactions.

Key words: Gastric cancer, Progression, Chemotherapy