Table of Content

20 August 2015, Volume 15 Issue 04

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论文

Expression and clinical significance of miR-150 in hepatocellular carcinoma

Huang Weihua, Jin Shaowen, Lan Qiusheng, Chu Zhonghua

2015, 15(04):  381-384.  DOI: j.issn.1009-976X.2015.04.002

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【Abstract】〓Objectives〓To investigate the expression and clinical significance of miR-150 in hepatocellular carcinoma(HCC). Methods〓miR-150 expression in liver cancer and paired normal tumor-adjacent tissues was determined by quantitative Real-time PCR (qRT-PCR). The expression difference between HCC and tumor-adjacent tissues was further verified using in situ hybrization(ISH) technique. Association of miR-150 expression in HCC tissues with clinicopathological status was examined by correlation analysis. Prognostic significance of miR-150 expression in HCC samples was detected with Kaplan-Meier method and Cox regression analysis. Results〓qRT-PCR assay showed 8/12 HCC cases had lower miR-150 expression compared with tumor-adjacent tissues and miR-150 expression level in HCC tissues markedly decreased (P=0.034). Similar to qRT-PCR results, ISH technique demonstrated most HCC specimens had negative or weak staining of miR-150, and staining intensity in 62% tumor-adjacent tissues was much higher than that in paired HCC tissues (P<0.001). Correlation analysis suggested miR-150 expression was significantly negatively correlated with AFP level, tumor size, TNM stage, histological grade and intravascular thrombus (P<0.05). Postoperative overall survival (OS) of miR-150 positive group was much longer that of miR-150negative group (P=0.004, Kaplan-Meier method). Cox univariate regression analysis implicated low miR-150 level in HCC samples was an unfavorable prognostic indicator (P=0.005). Conclusion〓Low expression of miR-150 in HCC specimens is related with a more aggressive tumor phenotype and indicates poor prognosis for HCC patients.

Non-metal biliary tents drainage in the management of acute obstructive suppurative cholangitis (35 cases)

He Wei, Wang Weidong, Wu Zhiqiang, Liu Qingbo, Kong Liqi

2015, 15(04):  385-388.  DOI: j.issn.1009-976X.2015.04.003

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【Abstract】〓Objective〓To evaluate the efficacy of non-metal biliary tents drainage in the management of acute obstructive suppurative cholangitis(AOSC). Methods〓There were 30 biliary lithiasis patients, four malignant biliary tumor patients and one narrowing bileduct patient in all 35 patients. All the patients during the procedure were firstly examined with endoscopic retrograde cholangiopancreatogarpy(ERCP),and then placed non-metal biliary tents in bileduct. Results〓Thirty-five patients were all successfully embedded with non-metal biliary tents. There were no severe complications such as acute pancreatitis, perforated bileduct and duodenal wall, haemorrhage. The total and direct bilirubin,white blood cell and transaminase enzymes in all patients dropped significantly after biliary drainage. Conclusion〓Non-metal biliary tents drainage in the management of acute obstructive suppurative cholangitis is a safe and effective procedure.

Application of indocyanine green clearance test for assessing preoperative liver reserve function in hepatocellular carcinoma patients

Wu Zhiqiang, Wang Weidong, Lin Jie, Ma Jing

2015, 15(04):  389-393.  DOI: j.issn.1009-976X.2015.04.004

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【Abstract】 Objective〓To evaluate the effect of indocyanine green clearance test at 15 min (ICGR15) on assessing preoperative liver reserve function in patients with hepatocellular carcinoma(HCC). Methods〓Sixty-three diagnosed HCC patients who had undergone hepatectomy from June 2012 to July 2013 were enrolled in this study. According to the quantity of ICGR15, the patients were divide into different groups, and the recovery of postoperative liver function were compared during different groups. The clinic data were analyzed by logistic regression analyze. Results〓The incidence rate of liver dysfunction in the ICGR15≥10% group was significantly increased than that in the ICGR15<10% group(68.2% vs 19.5%, P<0.05). The quantity of ICGR15 in Child-pugh B group were significantly increased than that in Child-pugh A group(19.01%±11.14% vs 7.57%±8.34%, P<0.05), and ICGR15 was correlated with Child-pugh score (P<0.05, r=0.313). The specificity of ICGR15 to predict recovery of postoperative liver function was 82.5%,which increased significantly than that of OGTT(P<0.05), and 65.2% with sensibility, 68.2% with positive predictive value, 80.5% with negative predictive value of ICGR15, which were all no statistical significance when comparing with OGTT (P>0.05). ICGR15 was associated with postoperative liver function (P<0.05, r=0.434), while OGTT negatively correlated with postoperative liver function (P>0.05). Logistic regression analyze revealed that ICGR15, vessel cancer embolus, blood loss and other operative complication were independent risk factors for postoperative liver dysfunction. Conclusion〓In the present study, ICGR15 showed a high sensitivity and specificity in assessing preoperative liver reserve function in patients with hepatocellular carcinoma, and was exact to predict recovery of postoperative liver function.

Value of perioperative serum total bilirubin of children with congenital biliary atresia predicting fat-soluble vitamin deficiency

Sun Xueyun, Li Li

2015, 15(04):  394-397.  DOI: j.issn.1009-976X.2015.04.005

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【Abstract】 Objective〓To explore the value of perioperative serum total bilirubin (TB) of children with congenital biliary atresia (CBA) predicting fat-soluble vitamin deficiency. Methods〓Seventy-two CBA babies in our hospital from January 2008 to June 2014 were selected as observation group, and 30 health babies in our hospital in the same period were selected as control group. The patients in observation group accepted surgical treatment and fat-soluble vitamin supplement. Serum levels of TB and bile acid (SBA), vitamin A, vitamin D, vitamin E, vitamin K in preoperative and postoperative 1 d, 3 d, 6 d, 12 d, 1 month, 3 months and 6 months were detected. Relationship between serum TB and SBA in CBA children and fat-soluble vitamin levels were analyzed, and value of serum TB and SBA level predicting fat-soluble vitamin deficiency was also analyzed. Results〓Preoperative and postoperative serum TB and SBA level of observation group higher than that of the control group(P<0.05). And postoperative 6 d or later serum TB and SBA levels of the observation group were lower than that of preoperative; And the difference was statistically significant (P<0.05). Compared with control group, perioperative serum fat-soluble vitamins level of observation group were lower; Compared with preoperative, postoperative one month or later serum fat-soluble vitamins level of observation group were increased. And the difference was statistically significant (P<0.05). Pearson correlation analysis results showed that the levels of serum TB and SBA in CBA babies were negatively correlated with serum fat-soluble vitamins level(P<0.05). ROC curve analysis results showed the area under the curve, sensitivity and accuracy of serum TB level of CBA infants predicting fat-soluble vitamin deficiency were higher than that of serum SBA level of CBA infants predicting fat-soluble vitamin deficiency(P<0.05). Conclusion〓Perioperative serum TB levels of CBA infants is high and the value of serum TB levels predicting fat-soluble vitamin deficiency is good. Serum TB can be used as reference in fat-soluble vitamin lack assessment of CBA infants and their treatment.

Effect of histone preconditioning on liver function in a rat model of biliary obstruction

Gao Haibin, Deng Xuesong, Ni Yong, Haung Wenlong, He Jingsong, Zhuang Shutong

2015, 15(04):  398-403.  DOI: j.issn.1009-976X.2015.04.006

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【Abstract】 Objective〓To study the effect of histone preconditinoning on liver function in biliary obstruction rats. Methods〓104 Wistar rats were randomized into 4 group, normal group (group A), sham operation group (group B), bile duct ligation group (group C) and the His group (group D, (200 μg/kg of histone proteins was administered intraperitoneally 24 hr before subjected to BDL). After the surgery, blood samples and live tissue specimens were collected at the time points of 0 h, 12 h, 24 h, 48 h and 72 h. Serum ALT, TB and DB levels were detected. Histological changes of liver tissues were analyzed. Serum IL-6, TNF-α and His levels were detected by ELISA. The mRNA expression levels of TLR-4 in liver Kupffer cells was examined by reverse transcription polymerase chain reaction (RT-PCR). Results〓The pathological scores in C group were higher than those of A and B group (P<0.01) and D group (P<0.05). The serum IL-6 and TNF-α levels in C group were higher than those of B group and group D at each time (P<0.01, P<0.05). Compared to B group, the TLR4 mRNA expression in Kupffer Cells were increased in C group with significant difference (P<0.01). In D group, the mRNA expression levels of TLR4 in Kupffer Cells were lower than those of C group at each time point (P<0.05). Conclusion〓In our study, histone preconditioning protected against liver injury in biliary obstruction rats. The levels of IL-6 and TNF-α were suppressed by activate the TLR4 pathway in Kupffer cells, local and systemic inflammatory response were suppressed.

Effects of TNF-inhibitors on coagulation function and calcium ion in rats with severe acute pancreatitis

Huang Dongling, Lin Jianshan

2015, 15(04):  403-406.  DOI: j.issn.1009-976X.2015.04.007

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【Abstract】〓Objective〓To investigate the effect of TNF-α inhibitor on coagulation function in a model of rats with severe acute pancreatitis (SAP). Methods〓SAP rat model was made. The control group rats (sham-injected group, n=20) were prepared to be made into SAP model with a small amount of saline injection. Sixty rats for SAP model: 20 rats for therapy group 1, group 2, group 3 respectively. After the model was successfully made, TNF-α inhibitor was injected into SAP model through dorsal vena of penis by dose levels of 0.15 mg/kg, 0.30 mg/kg and 0.45 mg/kg respectively.After 24 hrs, anesthesia was performed, and 3 ml common carotid artery blood of rats in all groups were extracted for the tests of coagulation and calcium related. Results〓During the test, all rats survived. Rats in therapy group were in better status, some of them still had autonomic activities and feeding. APPT and FIB level in therapy group 1, group 2 and group 3 were lower than that of sham-injected group, and comparative differences of PT, APPT, FIB, serum calcium among three therapy groups have statistical significance (P<0.05). Between the 3 groups of serum total calcium difference within treatment groups was not statistically significant (P>0.05). Conclusion〓SAP can cause declined coagulation function of rats and serum calcium level decreased. TNF-α inhibitor helps to improve the rats' coagulation function of SAP model, and the mechanism of action is related to fluid infusion and inhibiting inflammatory reaction and a quite significant dose-dependent is represented.

Diagnosis and treatments of hepatocellular adenoma(a case report and literature review)

Huang Xiaoxiao, Zhu Yingchang, Wang Jie

2015, 15(04):  407-410.  DOI: j.issn.1009-976X.2015.04.008

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【Abstract】〓Hepatocellular adenoma is a rare disease and a slow-growing tumor. Once hepatocellular adenomafound is found, it usually grows large, and can easily intratumoral hemorrhage, no specific clinical manifestations in patients. Preoperative CT or MRI can hardly diagnose, and it often requires biopsy. Surgical resection is an effective and practical treatment, and it often has good surgical results and prognosis. We report a case about HCA with intratumoral bleeding and conduct the literature review.

Experience in diagnosis and treatment of 124 cases with severe acute cholangitis

Zheng Zhaoming, Yuan Yangchun, Xie Tian

2015, 15(04):  411-413.  DOI: j.issn.1009-976X.2015.04.009

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【Abstract】 Objective〓To report the experience in diagnosis and treatment of severe acute cholangitis. Methods〓A retrospective analysis of the clinical data of 124 cases of patients with acute severe cholangitis treated in our hospital from 2008 to 2013 were performed. Results〓112 cases underwent the surgical treatment, of which 109 cases were cured. In cured patients, 81 cases were performed by T tube drainage, 4 cases received the two stage hepatectomy because of intrahepatic bile duct residual stone, 14 cases underwent two stage operation due to residual stone in both intrahepatic bile duct and common bile duct and 6 cases in the common bile duct alone, 2 cases were performed PTCD, 2 cases were performed ENBD (nasal biliary drainage). Three cases died in operation patients, including MODS after gallbladder fistula in one case, septic shock after PTCD in two cases. Twelve patients received conservative treatment, and 4 cases died. Conclusion〓Early diagnosis and early operation treatment the most step for acute severe cholangitis. Quick, simple and effective approaches are optional surgery.

The comparison and analysis between the clinical effects of the Mammotome atherectomy and the traditional surgery in the treatment of the breast mass

Wan Jian, Yang Jianmin, Wang Yongnan, Shang Ning

2015, 15(04):  414-416.  DOI: j.issn.1009-976X.2015.04.010

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【Abstract】 Objective〓To compare and analyze the clinical efficacy of the Mammotome atherectomy and traditional surgery in the treatment of the breast mass. Methods〓420 cases of patients with breast mass were diagnosed from Jan 2011 to Jan 2012,.which were randomized into group A (n=210)and group B (n=210). The patients of group A was treated with Mammotome atherectomy therapy, and those of group B were treated with traditional surgery. The operation time, blood loss, postoperative scar size, incision healing, postoperative analgesia and complications were analyzed and compared between the two groups. Results〓When compared with group B, the surgical treatment in group A showed excellent results which were as follow, shorter operation time, less intra-operative blood loss, smaller incision scar, shorter healing time, less analgesia use (all P<0.05). The follow-up in group A was 3 to 32 (an average of 17.49±3.27) months, and was 3 to 29 (an average of 16.83±3.41) months n B group. The mammary gland residual lesion was not found in both two groups. Conclusion〓Using the Mammotome atherectomy therapy in the treatment of the breast mass is superior to the traditional surgery, and it is safer and more effective.

The predictive value of preoperative serum fibrinogen for the prognosis of breast cancer after curative resection

Cao Yuyan, Gu Canji

2015, 15(04):  417-419.  DOI: j.issn.1009-976X.2015.04.011

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【Abstract】〓Objective〓To investigate the prognostic value of preoperative serum fibrinogen in patients with breast cancer patients after curative resection. Methods〓A total of 168 cases of patients with breast cancer were enrolled in this study. The medical records of patients were reviewed and the relationship between preoperative serum fibrinogen levels and clinical pathological features and prognosis were analyzed. Results〓The preoperative level of fibrinogen was significantly associated with TNM stage and lymph node metastasis. Preoperative fibrinogen was significantly higher in the group with advanced TNM stage and lymph node metastasis. Fibrinogen, lymph node metastasis were recognized as independent risk factors affecting the prognosis(P<0.05). Conclusion〓In the present study, preoperative level of fibrinogen correlated to TNM staging and lymph node metastasis. A high preoperative fibrinogen level could predict poor prognosis for patientswith breastcancerafter curative resection.

Comparative study between breast-conserving surgery and modified radical operation in patient with early breast cancer under the age of 35

Xu Tai, Lai Yeqian, Huang Jiewen, Fan Wanlin, Li Lu

2015, 15(04):  420-423.  DOI: j.issn.1009-976X.2015.04.012

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【Abstract】〓Objective〓To study the curative effect, prognosis and survival conditions of early breast cancer under the age of 35 with breast-conserving surgery and modified radical operation. Methods 110 cases of early breast cancer patients in our hospital after surgical treatment were included in the study and divided into breast-conserving surgery group (61 cases) and modified radical operation group (49 cases) according to the surgical procedures. The preoperative conditions, exterior effect, long-term efficacy and quality of life of the two groups were observed and compared. Results〓The operation time,.intraoperative blood loss and hospital stay of breast-conserving surgery group were significantly decreased than that of modified radical operation group,.and the postoperative complications and the rate of good appearance were obviously improved than the modified radical group..There was no significant difference in three years relapse-free survival rate and survival period between the two groups..The SF-36 quality score of breast-conserving surgery group was higher than that of modified radical operation group. Conclusion〓For early breast cancer patients under the age of 35,.breast-conserving surgery was cosmetic,.small trauma,.fewer complications and survival as well as good quality, and can keep the similar to the traditional way of survival,.but it remains to be further confirmed with multicenter and large sample research.

The protection method for recurrent laryngeal nerve in surgery of recurrent nodular goiter patients

He Jiandong, Lin Zeyu, Wu Xiao, Chen Zhiping, Yu Jiandong

2015, 15(04):  423-425.  DOI: j.issn.1009-976X.2015.04.013

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【Abstract】〓Objective〓To explore the protective method for the recurrent laryngeal nerve in recurrent nodular goiter patients surgery. Methods〓A retrospective analysis was conducted on 32 patients who underent the second surgery of recurrent nodular goiter. Results〓By experienced operation, there was a clear sign of Berry ligament and Zukerkandl tubercle in all 32 patients, and the recurrent laryngeal nerve was exposed well enough with this way. Three out of 32 patients were complicated by temporary hoarseness after the surgery and recovered after neurotrophic treatment and physical therapy for less than 4 weeks. Conclusion〓The second surgery of recurrent nodular goiter patients is challenged by the adhesions of thyroid and its peripheral tissues. Locating the Berry ligament and Zukerkandl tubercle by experienced operative skills is an essential method to protect the recurrent laryngeal nerve from surgical iatrogenic injury.

Postoperative 131I effect of salivary gland function and thyroglobulin antibody for thyroid carcinoma

Lin Xunhui, Ao Ping

2015, 15(04):  426-428.  DOI: j.issn.1009-976X.2015.04.014

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【Abstract】〓Objective〓To investigate the effect of the postoperative 131I treatment on salivary gland function and Thyroglobulin antibody (TgAb) for thyroid carcinoma. Methods〓Seventy-nine cases of thyroid carcinoma surgery patients in our hospital were included. Forty patients were treated with 150 mCi 131I (150 mCi group) and thirty-nine patients with 80 mCi 131I (80 mCi group). Salivary gland function and TgAb levels of patients were compared between the two groups. Results〓Effective rate of 150 mCi group was slightly higher than of 80 mCi group, but it had not statistically significant difference between the two groups. Saliva pH value and salivary buffer pH value of 150 mCi group were significantly higher than 80 mCi group. Salivary flow rate was significantly lower than 80 mCi group(P<0.05),and 3,6 months after 131I therapy, the average TgAb of 150 mCi group were significantly lower than 80 mCi group (P<0.05). Conclusion〓In our study, the effect of 131I therapy was remarkable for treatment of thyroid carcinoma, and it had less adverse reaction in low dose 131I therapy, but the TgAb more dropping degree in high dose 131I therapy.

Laparoscopic surgery versus open surgery for treatment of colorectal cancer: outcomes of a retrospective study of 320 cases

Yuan Chunyang, Luo Yuqing, Lin Guihai, Zhen Yuming, Xie Tian, Liu Jiayu

2015, 15(04):  429-432.  DOI: j.issn.1009-976X.2015.04.015

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【Abstract】〓Objective〓To compare the clinical effects between laparoscopic versus open radical resection for colorectal cancer. Methods〓A retrospective clinical data of 320 cases during the period from 2009 July to 2014 December were analyzed. Among them, 156 patients underwent laparoscopic radical resection of colorectal cancer (laparoscopic group), 164 cases of patients with open radical resection of colorectal cancer (laparotomy group). The number of lymph node dissection, length of incision, operation time, intraoperative bleeding, postoperative anal exhaust time, postoperative intestinal function recovery time, complications, hospitalization stay were observed and compared between the two groups. Results〓The number of lymph node biopsy in laparoscopic group and laparotomy group respectively were 12.89±3.44 and 14.33±3.38, no significant difference were found between the two groups (both P>0.05). The length of incision in laparoscopic group and laparotomy group were 5.10±1.60 cm and 15.2±2.51 cm. The operation time was 196.75±21.54 min and 153.82±14.85 min. The amount of bleeding was 85.63±35.73 ml and 182.02±65.73 ml respectively. Out-of-bed activity time was 4.0±1.41 and 6.8±1.82 days. The time of anus exhaust were 2.63±1.33 and 4.70±1.39 days. The length of hospital stay were 10.76±2.10 and 16.42±1.95 days, and total cost of hospitalization were 3.69×104±3000 and 3.03×104±3700 yuan. Compared between two groups, the differences were statistically significant (all P<0.05). Incidence of complications was found no difference between the two groups (5.8% vs 12.1%,P>0.05). Conclusion〓In this study, compared with the traditional open operation, laparoscopic resection of colorectal cancer was safe and effective, with advantage of less trauma and faster recovery, the long-term therapeutic efficacy was comparable with open operation.

Effect of single port laparoscopic hernia sac high ligation on pediatric occult hernia

Weng Hanqin, Jiang Jilin, Sun Hongwu, Yin Runlong, Mo Yanxia

2015, 15(04):  433-435.  DOI: j.issn.1009-976X.2015.04.016

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【Abstract】〓Objective〓To evaluate the effect of laparoscopic hernia sac high ligation on pediatric occult hernia. Methods〓1864 high ligation surgeries on children occult hernia were operated in our hospital between 2008 and 2012. There were 534 (28.6%) occult hernias. Of them, 436 cases were repaired with single port macroscopic surgery and 98 cases underwent traditional open surgery. The discovery rate, hospital stay, complications and the total cost of the two types of surgery were compared and analyzed. Results〓There were significant differences between single port macroscopic surgery and traditional open surgery in the discovery rate of occult hernia, total cost, hospital days and operative complication(P<0.05). Conclusion〓Single port laparoscopic sac high ligation operation has advantage over the traditional open surgery. It is suggestive the surgical approach would be adopted due to its advantage of finding contralateral occults hernia.

Application of laparoscopic transabdominal preperitoneal inguinal hernia repair in primary hospital of Guangdong

Bao Hankang, Li Yingru

2015, 15(04):  436-439.  DOI: j.issn.1009-976X.2015.04.017

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【Abstract】 Objective To investigate the clinical application and effect of laparoscopic transabdominal preperitoneal inguinal hernia (TAPP) repair in primary hospital. Methods〓385 patients with inguinal hernia from January 2011 to June 2013 were divided into two groups, laparoscopy group (n=178) and open operation group(n=207) according to the surgical approach. Operating time, hospital stay, medical costs, recovery of daily life and postoperative complications were compared between two groups. Results〓Laparoscopy group showed higher medical costs than open group, but had faster recovery of daily activities and less postoperative complications after TAPP. Five cases were transferred to open operation. Conclusion〓TAPP procedure has an advantage of less postoperative complications and faster recovery. For experienced primary hospital, laparoscopic TAPP can be applied.

Clinical Significance of microwave therapy in the rehabilitation after abdominal surgery

Lian Zhenbiao, Xiang Hua, Zhou Renshi, Peng Rongzhou

2015, 15(04):  439-442.  DOI: j.issn.1009-976X.2015.04.018

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【Abstract】 Objective〓To explore the clinical Significance of microwave therapy in the rehabilitation after abdominal surgery. Methods〓199 patients after abdominal operation were divided into treatment group (99 cases) and control group (100 cases). The patients of treatment group received abdomen microwave hyperthermia in 24 h after surgery and the controls were not treated. The recovery of bowel sounds, anus exhaust, wound healing and hospitalization time were observed in all patients..Incisional pain scores and analgesic agent,wound infection and fat necrosis were also annalyzed. Results The recovery of bowel sounds,anus exhaust and wound healing time in treatment group patients with upper gastrointestinal perforation,appendicitis and gallstones/cholecystitis were significantly shorter than those in control group (P<0.05). Postoperative hospital stay for appendicitis and gallstones/cholecystitis in treatment group were significantly shorter than those in control group (P<0.001), and wound healing time after surgery for abdominal tumors in treatment group was shorter than in control group(P<0.001)..Recovery time of bowel sounds and anus exhaust after abdominal tumor surgery in treatment group were no difference between two groups..Upper digestive tract perforation and abdominal tumor postoperative hospitalization time had no differences between two groups. The postoperative wound pain scores in treatment group were lower, and the number of using analgesic drug was less than that in control group (P<0.05). Incisional fat necrosis and infection of appendicitis in treatment group was reduced compared with control group (P<0.05). Conclusion〓In our study, microwave therapy was effective for abdominal surgery rehabilitation in postoperative pain relief, fat necrosis, intestinal function recovery and incision healing.

Effects of Roux-en-Y gastric gastrointestinal reconstruction surgery on blood glucose and insulin resistance of patients with gastric carcinoma complicated by type 2 diabetes

Ou Guowei, Chu Zhonghua

2015, 15(04):  443-446.  DOI: j.issn.1009-976X.2015.04.019

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【Abstract】〓Objective〓To observe the effects of Roux-en-Y gastric gastrointestinal reconstruction surgery on blood glucose and insulin resistance of patients with gastric carcinoma complicated by type 2 diabetes. Methods〓Thirty-one patients with gastric carcinoma complicated by type 2 diabetes who underwent radical gastrectomy and Roux-en-Y gastric gastrointestinal reconstruction were collected. The weight, body mass index (BMI), fasting blood glucose (FPG), fasting insulin (FINS), fasting C peptide (FCP), 2 hour postprandial blood glucose (2hPG), 2 hour postprandial insulin (2hINS), 2 hour postprandial C peptide (2hCP), glycosylated hemoglobin (HbA1c) and insulin resistance index (HOMA-IR) were detected, the index changes were estimated before operation and six months after the operation. Results〓Of 31 cases, 27 patients received insulins treatment, 2 patients with oral medication and 2 with simple diet and exercise therapy before operation, and 14 patients with insulin treatment, 6 with oral medication and 11 with simple diet and exercise therapy at six months after the operation. The difference was statistically significant betwee pre- and post-operation. (P<0.05). The weight, BMI, FPG, FINS, 2hPG, 2hINS, HbA1c and HOMA-IR in patients at six months after the operation were lower than those in patients before operation (P<0.05). The FCP and 2h CP levels in patients at six months after the operation were higher than patients before operation (P<0.05). Conclusion〓Roux-en-Y gastric gastrointestinal reconstruction can improve blood glucose and insulin resistance in patients with gastric carcinoma complicated by type 2 diabetes.

Clinical effect of different treatment methods for the progress of gastric cancer

Wu Sheng

2015, 15(04):  447-449.  DOI: j.issn.1009-976X.2015.04.020

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【Abstract】〓Objective〓To investigate the clinical efficacy and adverse reaction of different treatment methods for the progress of gastric cancer. Methods〓Sixty-six cases of advanced gastric cancer were chosen and divided into observation group (n=33) and control group (n=33). The patients in observation group were treated by SOX (S-1+oxaliplatin) chemotherapy. The controls were given FOX (oxaliplatin plus calcium folinate and fluorouracil) chemotherapy. The clinical efficacy, adverse reaction and survival time between two groups were compared between two groups. Results〓The effective percentage of observation group was 84.9% (28/33) and showed no significantly difference compared with that of the control group (24/33, 72.7%, χ2 =1.451, P<0.05). The side effects included granulopenia, thrombocytopenia, gastrointestinal upset, abnormal liver function. There was significant difference of the median survival times between two groups (t=7.733, P<0.05). Conclusion〓In the present study, S-1+oxaliplatin chemotherapy showed good efficacy, less adverse reactions.

Effect of different nutrition support on postoperative recovery in patients with colorectal cancer

Huang Yubao, Yang Jiajun, Huang Xuejun

2015, 15(04):  450-452.  DOI: j.issn.1009-976X.2015.04.021

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【Abstract】〓Objective〓To investigate effect of indwelling stomach tube combined with enteral nutrition on postoperative recovery in patients with colorectal cancer. Methods〓Ninety-seven patients admitted to our hospital from December 2012 to December 2013 were clivided into the indwelling stomach tube combined with enteral nutrition group (group A, n=33), enteral nutrition without indwelling stomach tube group (group B, n=32), parenteral nutrition group (group C, n=32). Patients of group A were given EN powder support combined with indwelling stomach tube after operation. Patients of group B received EN powder support after removal of nasogastric tube,and those of group C were given parenteral nutrition alone. Gastrointestinal function recovery,infection, adverse reactions, complications and costs were recorded and analyzed. Results〓There was no significant difference between three groups in hemoglobin and albumin pre-and post-treatment. The first exhaust time and first defecation time in group A were shorter than B and C group (P<0.05), and were shorter in group B than that in group C(P<0.05). There was no significant difference between three groups in adverse reaction rate. Five cases (15.2%) in group A, 4 cases in group B (12.5%) and 9 cases in group C (28.1%) developed postoperative infection, and there were differences between three group A, Group B and group C. Hospitalization time and costs were less in A group than in B and C group (P<0.05), and were shorter in group B than that in group C (P<0.05). Conclusion〓Indwelling stomach tube combined with enteral nutrition can promote the recovery of patients with colorectal cancer.

Gastric Cancer incidence from 2010 to 2011 in Guangzhou

Wu Wulin, Wu Deqing, Feng Xinyu, Chu Zhonghua

2015, 15(04):  453-455.  DOI: j.issn.1009-976X.2015.04.022

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【Abstract】〓Objective〓To analyze Guangzhou gastric cancer incidence and distribution from 2010 to 2011, and provide advices for cancer prevention and effect evaluation. Methods〓Gastric cancer incidence data were obtained by active and passive collection from 162 hospitals which were able for cancer diagnosis or treatment. Death certificate only cases (DCO) were from the Vital Statistics Data Base. ICD-10 code was C16. Results〓There were a total of 1,835 new gastric cancer cases during 2010-2011 in Guangzhou, and the crude incidence rate was 11.39/105 (15.22/105 in male and 7.45/105 in female, respectively). Above 40~ years old, the rate was increasing along with age. The crude incidence rate of gastric cancer was more common in male than in female. Conclusion Gastric Cancer incidence rate in Guangzhou is lower than the national average. So the government need to promote healthy lifestyle, and early detection, to aim to keep the low gastric cancer incidence.

GLUD1 promotes migration and invasion of colorectal cancer cells via epithelial-mesenchymal transition (EMT)

Cai Canfeng, Tang Chaomin, Zeng Jun, Chen Guoxing, Chen Xiang, Liang Min,

2015, 15(04):  456-460.  DOI: j.issn.1009-976X.2015.04.023

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【Abstract】〓Objective〓To study the effect of shGLUD1 on CRC cell migration and invasion, and elucidate the underline mechanisms. Methods〓The effect of GLUD1 knock-down was confirmed by Western blot analysis and qRT-PCR. The functional role of shGLUD1 on CRC cell motility was evaluated by transwell invasion assay and wound healing assay. Western blot and qRT-PCR were used to determine the expression of EMT markers and STAT3 phosphorylation. Results〓shGLUD1 mediated by lentivirus could availably down-regulate GLUD1 expression both at protein and mRNA levels. GLUD1 knock-down could significant suppress CRC cell invasion and migration in vitro, and decrease STAT3 phosphorylation and EMT. Additionally, STAT3 pathway blockage could significant attenuate the migration and invasion ability of CRC cells, and suppress EMT. Conclusion〓These results indicate that GLUD1 plays a critical role in CRC progression via STAT3 mediated EMT induction.

Surgical treatment of undetermined origin of chronic incomplete intestinal obstruction: experience of 21 cases

Zha Baoguo, Wang Meihua

2015, 15(04):  461-464.  DOI: j.issn.1009-976X.2015.04.024

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【Abstract】〓Objective〓To evaluate the outcomes of operation for patients with undetermined incomplete chronic intestinal obstruction and non-operation history. Methods〓Twenty-one cases of chronic intestinal obstruction were included in the study from May 2000 to May 2014. The clinical date and surgical outcomes were retrospectively reviewed. Results Clinical manifestation of the patients was unspecific symptoms. The main symptoms at the presentation were abdominal pain, abdominal distension, vomiting, constipation and emaciation. Barium enema examination showed high and angled splenic flexure(<60°), stenosis and twisting of colon,ectocolon with dry stool. The patients underwent lysis of splenic flexure of colon in 13 cases,part transverse colon resection in 6 cases,subtotal colectomy in 2 cases. Seven cases(16.2%) complained abdominal pain,diarrhea,abdominal distention, and constipation in a half year’s follow-up after operation, and four had in one year after operation. Surgery had no effect on two cases and their complaint failed to relieve. Conclusion〓Surgical treatment should be a safe and feasible approach for undetermined origin of chronic incomplete intestinal obstruction.

Surgical experience of unstable intertrochanteric fracture in the advanced age with hip hemiarthroplasty

Tu Yonggang, Ren Shaodong, Chen Jian, Ma Bangxing

2015, 15(04):  464-467.  DOI: j.issn.1009-976X.2015.04.025

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【Abstract】〓Objective〓To discuss surgical techniques of unstable intertrochanteric fracture in the advanced age with hip hemiarthroplasty. Methods〓Sixty-four cases of hemiarthroplasty in aged (more than 75 years old) unstable intertrochanteric fractures were retrospectively analyzed. The operative time, the time beginning to walk after operation, postoperative pain, postoperative functional recovery and the complications were analyzed. Results〓The average time of operation was 75 minutes,mean intraoperative blood loss was 360 ml,the average time beginning to walk after operation was 6 days. The patients were followed up for six months to 4 years. According to the Harris hip scoring system (pain 44 points, function 47 points, deformity 4 points, joint activity 5 points) assessment, excellent rate was 84.5%. No postoperative infection, loosening of fixation and prosthesis sinking phenomenon were found in all cases. Conclusion〓Hemiarthroplasty is an effective way of intertrochanteric fracture in the advanced age and helps patients resume earlier.

A comparative study of femoral shaft fracture with intertrochanteric fracture treated with proximal femoral nail antirotation fixation

Tang Yongnan, Jiao Feng, Luo Dongbin, Zhang Wenjia, Chen Shuai

2015, 15(04):  468-470.  DOI: j.issn.1009-976X.2015.04.026

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【Abstract】〓Objective〓To investigate the effect of reconstruction nail and lengthened PFNA for treatment of femoral shaft fractures with femoral intertrochanteric fractures. Methods〓Sixty patients with femoral shaft fractures and intertrochanteric fractures were admitted in our hospital and divided into two group, the reconstruction nail group (n=30) treated with the reconstruction nail fixation and lengthened PFNA group treated with long proximal femoral nail antirotation. The operation time, intraoperative blood loss, fracture healing time, incision size, complications, Harris score, Lyshonlm score were compared between two groups. Results〓All cases were recovered and no severe complications occurred in two groups. The blood loss was higher and incision size was larger in lengthened PFNA group than that in reconstruction nail group (P<0.05). No statistically significant difference was found in operation time between two groups. Fracture healing time in reconstruction nail group longer than that in reconstruction nail group (P<0.05). Harris score of all postoperative time point was higher in lengthened PFNA group than in reconstruction nail group, and Lyshonlm scores in lengthened PFNA group were lower in 2 months after operation. Conclusion〓In the present paper, PFNA showed better the clinical efficacy oin treating femoral shaft fracture with intertrochanteric fracture.

Effect of unilateral producible external fixation apparatus on treating open tibia fracture(Gustilo ⅢB/C) with bone defect

Li Guijian, Chen Yazhou, Liu Peijuan, Luo Jiawu

2015, 15(04):  471-474.  DOI: j.issn.1009-976X.2015.04.027

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【Abstract】〓Objective〓To investigate the clinical efficacy of unilateral producible external fixation apparatus for treatment of open tibia fracture with bone defect. Methods〓Twenty-one cases with fresh open tibia fracture (GustiloⅢB/C) with bone defect between June 2011 and June 2014 were included in this study and analyzed retrospectively. The surgical procedure was performed as follow: after one-stage debridement,.esquillectomy or elimination of heavily polluted bone tissue and repairing damaged blood vessel and nerve,.the unilateral producible external fixation apparatus was used to perform external tibia fixation. Then, operation of the superior extremity tibia osteotomy for bone-extension was done and bone transport operation began 2 weeks after operation..The external fixation apparatus was removed when bone got union. Results〓The average follow-up period was 18 months(range, 10 months to 3 years). Complete heal was achieved in 17 patients by one-stage operation. Three cases underwent local rotation flap and one case received thickness skin graft due to necrosis of skin flap..Complete union was achieved in all 21 cases. No refracture was observed after the removal of the external fixator, and the average healing time was 8 months.(range,.5 to 13). Conclusion〓Unilateral producible external fixation apparatus is an effective surgical approach for treating open tibia fractures by the way of esquillectomy, tibia osteotomy, bone transport for bone-extension.

Analysis of the metatarsal fractures fixed by miniplate and screw

Zhu Weirong, Chen Qiming,Huang Yingjiang, Yu Linquan

2015, 15(04):  474-476.  DOI: j.issn.1009-976X.2015.04.028

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【Abstract】〓Objective〓To summarize our experience of the metatarsal fractures fixed by miniplate and screw. Methods〓Between May 2011 and May 2014, 26 patients with metatarsal fractures fixed by miniplate and screw. Results〓All the 26 patients were followed up from 6 to 24 months (an averase of 13 months). All the fractures united within 10 to 16 weeks postoperatively (a average of 12 weeks). The mean time of complete weight loading walking was 14 weeks(ranging from 11 to 18 weeks). All the patients experienced no foot pain when standing and walking. Also no loosening of internal fixation and fracture occurred in all patients. According to the scoring criteria by American Foot and Ankle Society(AFAS): 95~100(13 cases), 90~95(10 cases), 85~90(13 cases). Conclusion〓Anatomic reduction and stable internal fixation is the best solution for dislocated metatarsal fractures, as well as is associated with a better functional outcome. The metatarsal fractures fixed by miniplate and screw can make it anatomic reduction and close contact. It also can control rotation preventing deformity. So it can achieve satisfactory reduction and clinical outcomes. Metatarsal fractures fixed by miniplate and screw is the ideal way.

Comparison between microsurgical repair and regular repair in the treatment of severe nail bed injury

Long Wenhao, Feng Fan, Wang Weiming

2015, 15(04):  477-479.  DOI: j.issn.1009-976X.2015.04.029

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【Abstract】〓Objective〓To compare the clinical outcomes of severe nail bed injury treated with microsurgical repair and regular repair procedures. Methods〓Patients with severe nail bed injuries (120 cases, 148 fingers) in our hospital from June 2010 to March 2014 were divided into two groups. Patients in group A (60 cases, 82 fingers) and group B (60 cases, 66 fingers) were treated with microsurgical repair and regular repair,respectively. The postoperative clinical outcomes in terms of nail regeneration and complications were analyzed. Results〓The follow up period ranged from two to twelve months. In group A, 52 cases (66 fingers) healed primarily, while complications occurred in 8 cases (16 fingers), of which 1 case (1 finger) developed into nail bed necrosis. In group B, 32 cases (33 fingers) healed primarily, while complications occurred in 28 cases (33 fingers), of which 8 cases (10 fingers) developed into nail bed necrosis. According to the evaluation criteria of nail bed regeneration, 66 fingers were graded as excellent , 11 fingers as good, 4 fingers as fair, 1 finger as bad in group A. Twenty-four fingers were graded as excellent, 14 fingers as good,18 fingers as fair, 10 fingers as bad. Conclusion〓Microsurgical repair,with better nail regeneration and lower incidence of complications, is superior to regular repair for treating severe nail bed injury.

Efficacy and tolerability of risedronate under different administration ways in the treatment of male osteoporosis

Yan Jun

2015, 15(04):  480-482.  DOI: j.issn.1009-976X.2015.04.030

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【Abstract】〓Objective〓To evaluate the efficacy and tolerability of risedronate under different administration ways in the treatment of male osteoporosis (MOP). Methods〓Seventy-two elderly osteoporosis men were divided into daily group(n=38) orweekly group (n=34) that received oral risedronate 5 mg daily or 35 mg once a week, respectively, for one year. The subject?蒺s bone mineral density (BMD) and bone turnover markers were determined. The incidence of osteoporotic fracture and side effects after drug treatment in both groups were also observed. Results〓The mean percent changes from baseline in the BMD values of the lumbar vertebra 1-4 and femoral neck significantly increased both in daily group and in the weekly group. There were no statistically significant differences between the two treatment groups in terms of mean percent changes in BMD at the lumbar spine and femoral neck at any time point (P>0.05). The changes of bone turnover markers (NTx/Cr and BALP), outcomes and safety assessment were also similar in these two groups in one year fellow-up. Conclusion〓The weekly 35 mg and daily 5 mg risedronate dosing administration showed similar efficacy in improving BMDs and biochemical markers of bone turnover in osteoporosis men during one year of follow-up. Treatment with weekly 35 mg risedronate provides an alternative for osteoporosis men who prefer once-a-week oral dosing.

The application of nerve root stimulation system in the treatment of spinal cord injury caused by neurogenic bladder dysfunction

Wang Liang, Gu Xin

2015, 15(04):  483-485.  DOI: j.issn.1009-976X.2015.04.031

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【Abstract】〓Objective〓To discuss the value of nerve root stimulation system in the treatment of spinal cord injury caused by neurogenic bladder dysfunction (NBD). Methods〓Seventy-two patients with NBD were selected in our Hospitals. All patients were divided into control group (n=24) and stimulating group (n=48), two groups of patients were given oral tolterodain (2 mg/day) treatment. The stimulating group again divided into sacral nerve stimulation (SNS group, n=24) group and neuromuscular electrical stimulation (NES group, n=24) group, and got three-month follow-up. The urine flow mechanics, urethral pressure and average daily number of urination were analyzed. Results〓The residual urine volume and maximum bladder capacity in NES group were significantly better than that of SNS group (P<0.017), and residual urine volume and maximum bladder capacity in SNS group were significantly better than that of control group (P<0.017). After treatment for 60 days, the detrusor pressure level and the average urination frequency in NES group were significantly improved than in control group (P<0.017), and after treatment for 120 days, the effect in NES group were better than and control group and SNS group (P<0.017). Conclusion〓Nerve root stimulation treatment can improve bladder function of the patients with NBD.

Laparoscopic radical cystectomy and urinary diversion for the treatment of invasive bladder cancer (report of 15 cases)

Chen Nanhui,Deng Wangdong, Huang Zhicheng, Chen Zhiling, Peng Dong

2015, 15(04):  486-489.  DOI: j.issn.1009-976X.2015.04.032

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【Abstract】〓Objective〓To summarize the experience of laparoscopic radical cystectomy. Methods〓Fifteen patients were reported who underwent surgery from August 2010 to January 2015,13 males and 2 females, aged 61-79 years old (average 68 years old) with organ confined, muscle included invasive carcinoma of the bladder. Preoperative clinical diagnosis ranged T2-3N0M0. The surgical procedure was as follows:laparoscopic radical cystectomy and extended pelvic lymph node dissection with removal of prostate or total excision of the uterus and vaginal wall resection. Urinary diversion method included 4 cases of orthotropic ileal neobladder, 9 cases of ileum channel operation, and 2 cases of ureter skin ostomy. Results〓Fifteen operations were successfully performed. The operative time was 220-550 min (average 400 min). The blood loss was 100-800 ml (average 240 ml). Blood transfusion was 0-400 ml (average 200 ml) during and after operation. Oral intake was started on hospital day 3-8. Ureteral stents were removed 3 weeks after operation and the urine tubes in the patients with ileal neobladder were removed in the fourth week. There were no severe complications during 1-40 month of follow-up. Conclusion〓Laparoscopic radical cystectomy is the good choice for radical cystectomy due to small trauma, less bleeding and speedy postoperative recovery.

Expression and clinical significances of IMPDH2 protein in prostate cancer tissues and benign prostate hyperplasia tissues

Tang Yongfeng, Han Zhaodong, Chen Guo, Cai Zhiduan, Li Bowei, Ye Jianheng, Wu Yo

2015, 15(04):  490-493.  DOI: j.issn.1009-976X.2015.04.033

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【Abstract】〓Objective〓To study the expression and significances of IMPDH2 in benign prostate hyperplasia (BPH) tissues and prostate cancer tissues, and to illustrate the correlation with clinical significance. Methods〓The samples were derived from benign prostatic tissue and prostatic carcinoma tissue of the patients with BPH or prostatic cancer. Western Blot was used to detect IMPDH2 protein in prostate cancer tissue and BPH tissue. Immunohistochemical method was used to detect IMPDH2 in prostate cancer tissue and BPH tissue,and evaluate the correlations with clinical significances of prostate cancer. Results〓The expression of IMPDH2 protein was significantly increased in prostate cancer tissues. The expression rate of IMPDH2 was in relation with clinical stage, Gleason score, and metastasis. Conclusion〓Our study showed the expression of IMPDH2 protein has positive correlation changed trend, suggesting IMPDH2 protein detection may help judge pathologic grade and predict the prognosis of prostate cancer.

PSA-related diagnostic value of different tumor markers in prostate cancer

Liu Yihao

2015, 15(04):  494-497.  DOI: j.issn.1009-976X.2015.04.034

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【Abstract】〓Objective〓To investigate the clinical value of different PSA-related tumor markers in prostate cancer. Methods〓A retrospective clinical data were analyzed in 300 cases of suspected prostate cancer patients in Zhongshan Traditonal Chinese Medical Hospital from January 2011 to December 2014. According to the results of transrectal prostate biopsy, the patients were divided into two groups, prostate cancer group (n=84) and non-prostate cancer (212). The levels of F-PSA/T-PSA, PSAD and (F-PSA T-PSA)/PSAD were compared between two groups and assessed the diagnostic value of these indicators. Results〓The results of F-PSA/T-PSA, PSAD and (F-PSA/T-PSA)/PSAD showed statistically significant differences between two groups (P<0.05). (F-PSA/T-PSA)/PSAD showed the highest specificity for the diagnosis of prostate cancer in all of parameters (P<0.05). Conclusion〓in the present study, the high level of (F-PSA/T-PSA)/PSAD has diagnostic significance for early prostate cancer and showed high specificity.

Application of a modified catheter drainage in the thoracic surgery

Wu Zaiyi, Feng Yupeng, Li Ailian, Chen Junkai, Bao Wen, Muo Yijun

2015, 15(04):  498-500.  DOI: j.issn.1009-976X.2015.04.035

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【Abstract】〓Objective〓To investigate the effect of chest surgical drainage by using modified catheter drainage in thoracic surgery. Methods〓Twenty-eight cases undergoing thoracic operation from July 2014 to December 2014 were included in the study. All patients received the intrathoracic drainage by using a narrow hose catheter with a negative pressure ball and pocket instead of traditional thick tube with water-sealed bottle. Pain degree, out-of-bed time, duration of catheter drainage, catheter obstruction, repeated thoracentesis were recorded and analyzed. Results〓Postoperative pain degree was concerned with mild pain in 15 cases, moderate pain in 11cases, and severe pain in 2 cases. And 13 cases took pain-killer, 1-2 times in 12 cases, more than 3 times in 4 cases. The fastest time to walk down bedding was 0.5-12 hours. Indwelling drainage tube stayed from 6 hours to 21 days. The volume of 24-hours-drainage ranged from 2 to 2800 ml. No catheter was found obstruction. None of patients need pleural puncture again after removal of the fine hose tube. Conclusion〓In our study, the fine hose catheter with a negative pressure ball and pocket device had a good clinical effect with small wound, free drainage, and could be indwelled for a long time.

Effect of ultrasound-guided multi point block in the fascia iliac gap combined with laryngeal mask anesthesia in elderly patients with intertrochanteric surgery

Sun Chengyi, Peng Lin, Wang Hua, Lu Bo, Lin Yao

2015, 15(04):  501-503.  DOI: j.issn.1009-976X.2015.04.036

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【Abstract】〓Objective〓To explore the effect of ultrasound-guided multi point block in the fascia iliac gap combined with laryngeal mask anesthesia in elderly patients underwent intertrochanteric femoral surgery. Methods〓Seventy cases of elderly patients aged 65-89 years old and ASA Ⅱ~Ⅲ grade, were selected. The patients are divided into two groups, iliac fascia gap anesthesia (S group, 35 cases) and iliac fascia gap combined spinal-epidural anesthesia (Y group, 35 cases). The blood pressure and heart rate are recorded in the following five points of time, before anesthesia, anaesthetizing, after the injection of 10 min, after the injection of 20 min and laryngeal mask airway being imbedded. The use rate of vasoactive drug, the volume of liquid used during the operation, the analgesic effect of 48 hours after surgery and the adverse reaction were also recorded. Results〓The blood pressure and heart rate of S group were significantly lower than those of Y group when anaesthetizing (P<0.05). The blood pressure of S group was higher than that of Y group but the heart rate was lower than Y group when and after the injection of 10 min, 20 min, after laryngeal mask airway was imbedded (P<0.05). The volume of liquid used during the operation in S group was less than that of Y group (P<0.05). The use rate of vasoactive drug and the adverse reaction of Y group were higher than those of S group (P<0.05). There were no differences between these two groups in VAS score 48 hours after surgery. Conclusion〓The approach of ultrasound-guided multi point block in iliac fascia gap combined with laryngeal mask anesthesia had good outcomes in treating elderly patients with intertrochanteric fracture.

Clinical significance of serum amyloid A for the diagnosis of sepsis in emergengcy patients

Xie Chunming, Liu Hongfeng

2015, 15(04):  504-506.  DOI: j.issn.1009-976X.2015.04.037

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【Abstract】〓Objective〓To investigate the diagnostic value of serum amyloid A(SAA) by comparison between SAA and procalcitonin (PCT). Methods〓Sixty-eight patients with sepsis were included in the study and were divided into two groups according to final diagnosis, sepsis group and non-infectious origin of systemic inflammatory response syndrome group (SIRS group). Serum SAA and PCT levels were determined and evaluated diagnostic significance by receiver operating characteristic curves (ROC). Results〓The levels of serum SAA and PCT in septic patients were significantly increased than that in non-infectious SIRS patients (P<0.001). Areas under ROC of SAA and PCT in the diagnosis of sepsis were 0.773±0.057 in SAA, 0.938±0.026 in PCT (SAA versus PCT,P<0.05). The accurate diagnostic rate of SAA was 70.6% and PCT 85.3%, while there were significant difference between them. Conclusion〓SAA, PCT have a same value for diagnosis of sepsis, but the later has advantage over the former.

Dynamic changes and clinical significance of CD8+CD28-T cells for patients with cerebral hernia

Qiu Bing, Xing Tiaosi, Zhang Nu, Luo Saihua, Liang Zai

2015, 15(04):  507-510.  DOI: j.issn.1009-976X.2015.04.038

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【Abstract】〓Objective〓To investigate the dynamic changes of peripheral blood CD8+CD28-T cells and clinical significance in patients with cerebral hernia. Methods〓A total of 77 patients of severe brain injury were divided into two groups: cerebral hernia (A group, n=36) and no-cerebral hernia (B group, n=41), 32 healthy subjects were in control group (C group), the level of CD4+ CD25+ and the percentage of TGF-β1, IL-10 in peripheral blood was analyzed with flow cytometry. All variables were observed in group A and B at post-traumatic 3, 6, 12 h. Results〓Difference of three groups in CD8+ CD28- T cells, TGF-β1 and IL-10 overall was significant (P<0.05), but no statistically significant difference between group B and group C, all variables in group A was significantly lower than group B and group C (P<0.05). The level of CD8+ CD28-T cells, TGF-β1 and IL-10 had no significant difference in group B for 3, 6, 12 h. Compared with group B, CD8+ CD28- T cells, TGF-β1 and IL-10 in group A of three different time points showed a progressive decline, difference between any two time points was significant. Conclusion〓One important cellular immunological characteristics of cerebral hernia is the significant decrease of CD8+ CD28-T cells, especially the progressive decline of which within 12 h are closely related to disease progression.

Clinical significance of ultrasound-guided right subclavian vein catheterization in emergency patients

Rao Guanghao, Xu Zhaozhu, Xie Feng, Wang Dongxiao

2015, 15(04):  510-512.  DOI: j.issn.1009-976X.2015.04.039

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【Abstract】 Objective〓To discuss the clinical significance of ultrasound-guided right clavicle vein puncture catheter in the emergency patients. Methods〓Seventy-two cases with shock who received right clavicle vein puncture catheter were divided into two group, ultrasound-guided clavicle vein puncture catheter group (observation group, n=38) and clavicle vein puncture catheter group without ultrasound guidance (control group, n=34). The success rate of puncture, puncture time and puncture complications were observed and compared between two groups. Results〓The first success rate was 92.1% in the observation group and 61.7% in control group. The time of puncture, performance time in observation group were lower than that in control group(P<0.05). There were no significant differences in complications between the two groups. Conclusion〓Doppler-guided right subclavian vein catheterization is a effective way for emergency patients for fast setting venous access.

The research advances of Raf kinase inhibitory protein (RKIP) in cancer

2015, 15(04):  513-516.  DOI: j.issn.1009-976X.2015.03.040

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【Abstract】〓Raf kinase inhibitory protein (RKIP) was initially identified as phosphatidylethanolamine binding protein in bovine brain. Later RKIP has emerged as a critical molecule for regulating activation of MAPK, NF-κB and G protein coupled receptors (GPCRs). The disruption of RKIP in a wide range of pathologies, including cancer metastasis and therapeutic resistance makes it an exciting target for individualized therapy and disease-specific interventions. By combing clinical data analysis, RKIP became a new biological marker that reflects the prognosis of tumor. This review attempts to highlight recent advances in the RKIP field underscoring its potential role as a master modulator of many pivotal intracellular signaling cascades that control cancer metastasis and therapeutic resistance, and as a prognostic factor of tumor.

Occult thyroid carcinoma with cervical lymphatic node metastases in one case report

2015, 15(04):  517-519.  DOI: j.issn.1009-976X.2015.04.041

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Nutritional administration of integration of medical care for patients with diabetes under orthopedic operation during perioperative period

Feng Huiping, Shu Yantian, Jiang Wei

2015, 15(04):  519-521.  DOI: j.issn.1009-976X.2015.04.042

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【Abstract】〓Objective〓To research the effects of nutritional administration of integration of medical care for patients with diabetes under orthopedic operation during perioperation. Methods〓Under integration of medical care, 78 patients with fracture combined with diabetes were included in the study after systematic evaluation. Individual nutritional treatment was done which concerned with education of nutritional knowledge, blood glucose control, exercise prescription, correction of excess nutrient, prevention of inanition and complications. Results〓All patients recovered, with wound healing well in 76 cases and postponed 2 cases, and no nutritional complication. Conclusion〓In our study, the patients with diabetes under orthopedic operation recovered smoothly under nutritional administration of integration of medical care, which could control blood glucose, improve nutritional condition, enhance resistibility, and avoid complication for these patients.

The combined application of vacuumsealing drainage and clinical nursing pathway in the treatment of foot and ankle soft tissue defects

zeng danyang

2015, 15(04):  522-525.  DOI: j.issn.1009-976X.2015.04.043

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Effect of catheter nursing risk assessment on risk controlling in extubation for patients with hepatic and gall diseases

2015, 15(04):  525.  DOI: j.issn.1009-976X.2015.04.044

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