Abstract: Objective: Analyse clinical pathological characteristics in different tumor of periampullary and its correlation with clinical prognosis. Methods: Retrospective review of clinicopathological and follow-up data in 110 patients with pancreaticoduodenectomy sufferring from periampulary cancer. Results：The operative time ,blood loss ,positive rate in surgical margin and lymph node metastsis is significant high in pancreatic caner group than non-pancreatic cancer group.Tumor stage,positive surgical margine and lymph node metastasis is significant independent risk factors for patients with pancreaticoduodenectomy.There was significant difference in pancreatic carcinoma and non-pancreatic carcinoma with pancreaticoduodenectomy. Conclusion:Tumor stage,positive surgical margine and lymph node metastasis is significant independent risk factors for patients with pancreaticoduodenectomy.Prognosis of non-pancreatic carcinoma was better than pancreatic carcinoma with pancreaticoduodenectomy

摘要： 目的：探讨壶腹周围癌中不同类型肿瘤的临床病理特征及与手术、预后的关系。方法：回顾性分析行胰十二指肠切除术的110例壶腹周围癌临床病理及生存时间。结果：全组包括胰头癌60例(54.5%)，胆总管下端癌19例(17.3%)， Vater壶腹部癌24例（21.8%）和十二指肠乳头癌7例(6.4%)；胰腺癌组与非胰腺癌组患者在手术时间、术中出血量、切缘阳性率及淋巴结转移阳性率之间差异有统计学意义，肿瘤分期、阳性切缘及淋巴结转移均是影响患者Whipple术后生存率的独立危险因素；胰腺癌患者与非胰腺癌患者Whipple术后5年生存率差异有统计学意义（P＜0.05）。结论：肿瘤分期与阳性切缘、淋巴结转移是影响Whipple术后生存的独立危险因素，非胰腺癌较胰腺癌术后预后更好。

关键词: 壶腹周围癌, 胰十二指肠切除术, 预后, Periampullary carcinoma, pancreaticoduodenectomy, prognosis