Pyroptosis in thyroid cancer： dual roles and advances in therapeutic interventions

doi:10.3969/j.issn.1009-976X.2025.04.008

Abstract

Abstract: Pyroptosis is a novel type of programmed cell death mode. It mediates membrane pore formation and pro-inflammatory factor release through Gasdermin family proteins and shows a bidirectional effect of promoting and inhibiting cancer in thyroid cancer. The standard therapeutic effect of thyroid cancer is still limited. Exploring the application of pyroptosis mechanism in tumor suppression and immune activation has become a new research direction. This article summarizes the differences in the role of pyroptosis in different thyroid cancer subtypes and the tumor immune microenvironment, Outlines the research progress of drug-induced pyroptosis such as chemotherapy, targeted therapy, and traditional Chinese medicine components, and looks forward to the potential of pyroptosis regulation in precision treatment.

Key words: pyroptosis, thyroid cancer, tumor immune microenvironment, drug intervention

摘要： 细胞焦亡是一种新型程序性细胞死亡模式,通过Gasdermin家族蛋白介导膜孔形成及促炎因子释放,在甲状腺癌中展现促癌与抑癌的双向效应。目前甲状腺癌的标准治疗效果仍有限,探索细胞焦亡机制在肿瘤抑制及免疫激活中的应用,成为新的研究方向。本文总结了细胞焦亡在不同甲状腺癌亚型及肿瘤免疫微环境中的作用差异,概述了化疗药物、靶向药物及中药成分诱导焦亡的研究进展,并展望基于焦亡调控的精准治疗潜力。

关键词: 细胞焦亡, 甲状腺癌, 肿瘤免疫微环境, 药物干预

CLC Number:

R736.1

JIN Xin-ru, ZHAO Zi-yi, ZHONG Shu-wen, WU Xian-jiang. Pyroptosis in thyroid cancer： dual roles and advances in therapeutic interventions[J]. Lingnan Modern Clinics In Surgery, 2025, 25(04): 258-266.

金欣茹, 赵子逸, 钟树文, 吴贤江. 细胞焦亡在甲状腺癌中的双向效应及靶向治疗研究进展[J]. 岭南现代临床外科, 2025, 25(04): 258-266.

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