关键词: 盐酸帕洛诺司琼, 术后恶心呕吐, 硬膜外自控镇痛

Abstract:

【Abstract】 Objective To observe the effect of palonosetron hydrochloride on preventing post-operative nausea and vomiting (PONV) in patients treated with patient-controlled epidural analgesia (PCEA). Methods Sixty patients who had cholecystectomy under epidural anesthesia were randomly assigned into group C(palonosetron group,n=20),.group B.(droperidol group,n=20).or group A (control group,n=20)..Before operations,.0.25 mg of palonosetron hydrochloride,.2.5 mg of droperidol or 100 mL of saline was intravenously administered to patients in group C,.group B or group C,.respectively..5 mg of morphine plus 0.125% of bupivacaine in 100 mL of saline was used for PCEA..During the period of PCEA,.the incidence and severity of nausea and vomiting were recorded,.and when vomiting occurred,.the efficacy was evaluated after administrating antiemetics..Results The number of patients who had nausea and vomiting in group A, group B and group C was 13, 5 and one respectively. PONV incidence in group C was lower than that in group B or group A (P<0.001). There was significant difference between group B and group A (P=0.022)..Conclusion Preoperative administration of palonosetron hydrochloride can significantly decrease the incidence of PONV induced by PCEA in patients undergoing cholecystectomy.

Key words: Palonosetron Hydrochloride, Postoperative nausea and vomiting, Patient controlled epidural analgesia