代谢组学在外科精准医学的研究进展

doi:10.3969/j.issn.1009-976X.2025.06.009

摘要/Abstract

摘要： 代谢组学是系统生物学的重要组成分支,主要研究生物内源性小分子的组成与动态变化。因其能够反映机体表型,对生理病理变化响应迅速,为外科精准医学的诊疗提供了重要策略。本文简述代谢组学技术的核心概念、主流手段、标准实验流程和质量控制原则,重点概括其在肿瘤与非肿瘤外科领域的主要研究进展,包括风险评估、病灶识别、预后监测及围手术期管理等方面,并分析代谢组学技术目前在临床转化过程中面临样本和数据库标准化、结果重复性验证以及多组学数据深度整合复杂等挑战。未来随着纳米传感器和人工智能解析技术的发展,代谢组学技术有望推动外科精准医学预见性模式转型。

关键词: 代谢组学, 外科, 精准医学, 临床转化

Abstract: Metabolomics is an important branch of systems biology, mainly studying the composition and dynamic changes of endogenous small molecules in organisms. Due to its ability to reflect the phenotype of the body and its rapid response to physiological and pathological changes, it provides an important strategy for the diagnosis and treatment of the surgical precision medicine. This article briefly describes the core concepts, mainstream methods, standard experimental procedures and quality control principles of metabolomics technology, and focuses on summarizing its main research progress in the fields of tumor and non-tumor surgery, including risk assessment, lesion identification, prognosis monitoring and perioperative management. It also analyzes the challenges that metabolomics technology currently faces in the process of clinical transformation, such as the standardization of samples and databases, the verification of result repeatability, and the complexity of deep integration of multi-omics data. In the future, with the development of nanosensors and artificial intelligence analysis technology, metabolomics technology is expected to promote the transformation of the predictive model of precision medicine in surgery.

Key words: metabolomics, surgery, precision medicine, clinical translation

中图分类号:

R602
R730

岑美凤, 潘文锋, 王小娟. 代谢组学在外科精准医学的研究进展[J]. 岭南现代临床外科, 2025, 25(06): 399-409.

CEN Mei-feng, PAN Wen-feng, WANG Xiao-juan. Research Progress of Metabolomics in Surgical Precision Medicine[J]. Lingnan Modern Clinics In Surgery, 2025, 25(06): 399-409.

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