关键词: 乳腺, 钙化, 微创, 住院时间, 住院费用

Abstract: Objective To explore the advantages and disadvantages of high-frequency ultrasound-guided vacuum-assisted biopsy versus open surgical biopsy for breast calcifications. Methods A retrospective study analysis was conducted on the clinical and pathological data of 161 breast calcification cases （154 patients, including 7 cases of bilateral sides）. Based on the surgical approach, patients were divided into two groups： the vacuum-assisted biopsy group （93 cases with 97 lesions） and the open surgical biopsy group （61 cases with 64 lesions）. The vacuum-assisted group underwent vacuum-assisted stereotactic biopsy under high-frequency ultrasound guidance to remove the calcifications, while the open surgical biopsy group underwent traditional open surgical excisional biopsy. All specimens of the margins were subjected to intraoperative radiography and pathological examination. The two groups were compared in terms of success rate of single-attempt biopsy for target calcifications, incision size, postoperative infection rate, hospital stay, and hospitalization costs. Results The incision size in the vacuum-assisted biopsy group was 0.31±0.03 cm, while in the open surgical biopsy group, it was 4.15±0.72 cm, showing a statistically significant difference （P<0.01）. The success rate of single-attempt biopsy for target calcifications was 96.91% in the vacuum-assisted group and 96.88% in the open surgical biopsy group, with no statistically significant difference （P>0.05）. The postoperative infection rate was 0% in both groups. Among patients with benign pathology result, length of the hospital stay in the vacuum-assisted group was 2.20±1.30 days, compared to 5.80±1.97 days in the open surgical biopsy group, showing a statistically significant difference （P<0.05）. The hospitalization costs for patients with benign pathology result were 9303.87±4328.08 CNY in the vacuum-assisted group and 12 614.5±4055.85 CNY in the open surgical biopsy group, with a statistically significant difference （P<0.001）. Conclusion Both vacuum-assisted biopsy under high-frequency ultrasound guidance and traditional open surgical biopsy to remove target breast calcifications are safe and effective methods. Vacuum-assisted biopsy offers advantages of smaller incision size, shorter hospital stays, and lower hospitalization costs.

Key words: breast, calcifications, vacuum-Assisted biopsy, hospital stays, hospitalization costs